Biography:

Yaqi Zhai, MD, chief doctor of department of Gastroenterology and Hepatology of Chinese PLA General Hospital, has completed his MD degree at the age of 26 years, from Chinese PLA medical school. He was dedicated to digestive endsocpic tunnel technique and had published more than 10 papers in reputed journals. He was also a member of academic group of Capsule endoscopy and enteroscopy of CSGE.

Abstract:

Peroral endoscopic myotomy (POEM) is a new minimally-invasive endoscopic method for achalasia, being expected to be the first treatment choice with satisfactory short and morderate term outcome.  We performed our first POEM in Oct 2010, and gradually found not all the achalasia patients were eligible and euqually safe to undergo POEM. Although achalasia had been staged or classified on radiography or manomentry, there was no endoscopic classification. We retrospectively analyzed the endoscopic features of 976 achalasia patients in our endoscopic center, and proposed a new endoscopic Ling classification. Acorrding to presence of muti-ring,crescent-like structure and diverticulum, achalasia was divided into three subtypes:type â… , type â…¡(a,b,c), type â…¢. Then prospective study enrolling 341 patients with POEM was performed to evulate the clinical value of the achalasia. Patients with different Ling subtypes suffered the similar degree of symptoms according to Eckardt scores. Yet the Ling classfication had significant correlation with symptom duration and lower esophageal sphincter pressure (LESP). The patients with longer duration were more likely to developed Typer â…¡c and â…¢. And LESP of these Typer â…¡c and â…¢ patients was obviously lower than the others. The overal success rate of POEM was 97.7% within 1-year follow-up and there was no significant difference among different subtypes. Whereas Ling classficaiton had significant correlation with complications, such as gas-related adverse and mucosal perforation. Ling â…¡c was showed to have the highest risk of complication and a modified POEM with short tunnel was demonstrated effectively by us.

Biography:

Dr Sandeep Arora carries a professional experience spanning 23.5 years—3.5 years in pharma production and quality assurance in Glaxo I Ltd, Blue cross Ltd, and 20 years in teaching/training and research—in the fields of pharmacognosy andNATURAL products, regulatory affairs, industrial pharmacy, and management. He is the author of the book titled, “Pharmaceuticals – Issues for Industrial Management” and has been the honorary editor of “Advanced Drug Review”—a quarterly drug pharmacology review index—since 2005; and has to his credit about 60 national and international publications. His area of specialization and research are medicinal natural products (phytochemical, pharmacological evaluation and standardization), development and regulatory aspects of herbal and other products, and industrial management. Under his guidance five Ph.D. students have completed their theses; 15 M. Pharm. students and 6 PhD candidates have completed their theses; and 8 Ph D projects are currently being guided by him. He has to his credit 4 patents as lead investigator, and 4 as coinvestigator and involved in 2 product launches at international level. He has convened 8 National/international conferences as Chairman, and is a regular expert speaker at OMICS, US and ASSOCHAM, India conferences, invited offshore speaker at Univ of Florida and is member APTI, and Pharmacy Council and Life member Inflammation Society, and consultant and advisor to Pharma industry on regulatory compliance and herbal product standardisation.

Abstract:

With increasing incidences of hepatitis, fibrosis and cirrhosis due to lifestyle changes, food habits, drug adverse effects, alcoholic and fatty damage, it is relevant that focus should now be on prophylactic and preventive measures, to take care of day to day factors causing cellular injury and inflammatory processes. Traditional foods and traditional therapeutic systems the world over including Ayurveda point to the benefits of regular herbal intake, which indirectly provided a prophylactic antiinflammatory activity and show antiarthritic action.

Slurry comprising herbal extracts was prepared by suspending in a solution of the excipients, dissolved or suspended in sufficient water and lsopropyl alcohol (IPA) to make the slurry sprayable. After milling through a machine adapted for grinding suspension in order to reduce the particle size of extract, the suspension was applied on the excipient pellets in the classic pharmaceutical fluidized bed coating device, which consists simply of a vertical cylinder with an air-permeable bottom and an upward spraying nozzle close above the bottom, or a downward-spraying nozzle mounted above the product mass. The temperature of the fluidizing air was balanced against the spray rate to maintain the mass of pellets at the desired level of moisture and stickiness while the coating was built up. A finishing layer over the extract layer of 1 % of an anti- static ingredient such as talc or silicon dioxide, simply dusted on the surface of the pellets and other coats were applied.

The pellets were made palatable and coloured with colourants and flavours added to increase patient compliance for daily intake as prophylactic food, and optimized for uniformity of content, dissolution and moisture content, and then for anti-inflammatory and hepatoprotective activity. The Hepatoprotective pellet (HDT) treatment stimulated hepatoprotective effects that were proven by attenuating serum AST and ALT activities. The antioxidant activities of the HDT pellets can ameliorate oxidative stress contributing to the amount of intracellular antioxidant enzymes, which was confirmed by GSH and CAT assay. Centrilobular necrosis, lymphocytes infiltration and steatosis were apparent in CCl₄-treated group, whereas administration of the HDT significantly reverses these abnormal indexes. This indicates that HDT can ameliorate oxidative stress to preserve hepatic function and hepatic injury induced by CCl₄.

Biography:

Alaa Mostafa Sewefy has completed his PhD at the age of 25 years from  minia University and postdoctoral studies from Minia University School of Medicine. He is associate proffessor of general and laparoscopic surgery at Minia University School of Medicine. He has published more than 3 papers in reputed journals

Abstract:

Background: Sacroccygeal pilonidal sinus disease (SPSD) is a worldwide health problem, affecting young adult, mainly male, with a tendency for recurrence. Various modalities have been used for treating this condition. Karydakis procedure is one of most commonly used asymmetric flap for treating this condition.

Objective: the study aimed to evaluate Karydakis procedure with tie-over compressing sutures instead of routine use of drain in treatment of SPSD

Design: prospective randomized controlled clinical study conducted between January 2010 and January 2015.

Settings: the study was conducted in Minia university hospital.

Patients: the study included 154 patients. Patients were randomly assigned into 2 groups. Each group included 77 patients.

Interventions: Group 1 operated by standard Karydakis procedure and group 2 by Karydakis procedure with tie-over compressing sutures without drain.

Main outcomes and measures: incidence of seroma formation, wound complications length of hospital stay, off-work time and recurrence rate

Results: all patients discharged on the same day of surgery in group 2 VS. mean hospital stay of 4.9 ± 2.4 day in group 1. No patients developed seroma in group 2 VS. 7.8% in group 1. 1.3% developed wound infection in group 2 VS. 9.1% in group 1. The average time for return to work in group 2 was 10.2 ± 1.4 days VS. 12.6 ± 4 days in group 1. No recurrences were noted in group 2 VS. 2.6% in group 1

•           The limitations: The feedback about postoperative pain and patient's satisfaction about the scar were not investigated. The extent of the disease on both group were not investigated. Relatively short duration of follow up to accurately weight recurrence rate.

Conclusion: Karydakis flap with tie-over compressing interrupted sutures without drain is safe, one day surgery with least complications rate.

Biography:

Daorong Wang, Chief Physician, Professor, Ph.D.Supervisor. The deputy director at the Gastrointestinal Center and department of Gastrointestinal Surgery at Subei People's Hospital of Jiangsu Province, China

Abstract:

This review aimed to summarize the basic research on and clinical applications of uncut Roux-en-Y gastrojejunostomy. We reviewed the available literature on uncut Roux-en-Y gastrojejunostomy, which is a modification of the Billroth IIwith Braun’s anastomosis in which a jejuna occlusion is fashioned to avoid Roux stasis syndrome. In this paper, we present the findings of our literature review. The original uncut technique was associated with dehiscence or recanalization of the jejunal occlusion, and was therefore not widely applied. However, with recent improvements in the method of jejunal occlusion, the uncut Roux-en-Y reconstruction may be an appropriate alternative for digestive tract reconstruction after distal gastrectomy. The uncut Roux-en-Y gastrojejunostomy is a controversial yet promising method of gastrointestinal reconstruction after distal gastrectomy.

Biography:

Alex has completed his MD (I) at the age of 31 years from Udine University after have obtained a CCT in General and Colorectal Surgery. He is now working as senior specialist registrar at the prestigious St Mark’s Hospital in the UK and he is aiming a new MD in Physiology and Neurostimulation at the Imperial College of London. He has published more than 20 papers in reputed journals and has been serving as an editorial board member of repute.

Abstract:

Single Port Laparoscopic Surgery (SPLS) is a technique which is increasing in popularity. The benefit of SPLS in complex Crohn’s disease (CD), which includes a significant cohort of young patients sometimes needing multiple operations, has not been comprehensively assessed. This study analyses our experience with this technique.

Patients who underwent SPLS for CD were included. Data were collected prospectively from January 2013 to December 2015. Ileocolic resections, right hemicolectomy, small bowel stricturoplasties and resections were included in the complex CD cohort. Primary and re-do operations were analysed separately.

Seventy-five patients were included in the study: (59 ileocolic resections, 16 small bowel stricturoplasty/resections). Of the total, 41 were primary resections and 34 were re-do resections. The median age was 39 years (Range 14 years – 74 years), and the median hospital stay was 7 days (Range - 3 days – 28 days). The total complication rate was 31.5% most of which were Clavien-Dindo type 1 and 2.  There was no difference in operating time, average blood loss, conversion rates, complication rate and hospital stay, between those who had primary or redo surgery.

In our experience SPLS can be performed safely in patients with complex Crohn’s disease even in redo surgery. There may be some technical advantages to the procedure in this group of patients

Biography:

Vito Annese has received his MD in 1981 and subsequently the CCST in Internal Medicine and Gastroenterology at the Catholic University of Rome Italy. He has over 30-years of experience in gastroenterology, with specific interest in functional and inflammatory bowel disorders. He authored more than 250 peer reviewed publications. In the last 10-years he has been head of Gastroenterology at the Research Hospital of S. Giovanni Rotondo and at the University Hospital Careggi of Florence and aggregate professor at the University of Foggia and Florence in Italy. Since September 2016 is Consultant Gastroenterologist at the Valiant Clinic of Dubai.

Abstract:

Cancers caused by immunosuppressant drugs represent a minority of the incident cancers observed in patients with IBD. Thiopurines can promote cancer in several different ways, such as carcinogenic mutations of cell DNA, impaired tumor-cell immune-surveillance, reduced number and/or function of immune cells, and facilitating the proliferation of cells with microsatellite instability. However, several studies conducted in referral centers and adequately powered nationwide studies have suggested that cancer risk in general is not increased. In a recent meta-analysis, the overall standardized risk ratio (SIR) for lymphoma considered in the population studies was significantly increased in IBD patients receiving thiopurines, (5.7, 95% CI 3.2-10.1), but not in former users or patients who had never used these drugs. The absolute risks were globally higher by a factor of 2 to 3 in men compared with women, irrespective of age and drug exposure. The highest absolute risks for lymphoma (any type) were found in patients over 50 years (2.6/1000 patients) and in males under the age of 30 (estimated crude risk: 1 to 2/1000 patients). Hepatosplenic T-cell lymphomas (HSTCLs) occur almost exclusively in males under the age of 35 who are exposed to thiopurines. However, over 80% of the cases of HSTCL occur after the first 2 years of combination therapy of thiopurines with anti-TNF. Data suggesting an excess risk of non-melanoma skin cancer (NMSC) in IBD patients being treated with thiopurines have emerged from several studies conducted in the last five years and a recent meta-analysis, which found a pooled adjusted HR for NMSC in thiopurine-treated IBD patients of 2.3. The carcinogenic effect of thiopurines has been attributed to increased UVA-induced DNA damage, increased production of reactive oxygen species in skin epithelial cells. Since 1995, several studies have investigated the cancer risk associated with TNF-alpha antagonists used in IBD. Most patients treated with these agents in these studies also used (or had used) thiopurines, so it is difficult to attribute the findings to anti-TNF therapy alone. More recently an adequately powered nationwide study in Denmark have confirmed the data of meta-analysis and pooled analysis for infliximab and adalimumab excluding an excess of risk. It is not clear whether concomitant anti-TNF treatment increases the risk of thiopurine-associated lymphoma, except for the hepatosplenic T-cell variety. The results of a recent meta-analysis indicate that the risk of melanoma is mildly increased (37%) in IBD patients, independent of the use of biologic therapy. In a large nested case-control study performed with data from a large health insurance claims database, the use of TNF-alpha antagonists was independently associated with an increased melanoma risk in patients with IBD (OR=1.9; 95% CI, 1.1-3.3), but in a Danish cohort the adjusted odds ratio was non-significant. Reliable data regarding risk of cancer and therapy with Methotrexate and Cyclosporine in IBD are lacking. Data on methotrexate related to rheumatologic experience do no report an excess risk of solid cancer or hematological malignancies. Calcineurin inhibition is associated with an unequivocal excess risk of cancer in the post-transplant state, but is generally dose and duration-dependent; therefore, is not an issue for IBD.

Biography:

Dr. Pujarini Dash is working as a SERB NPDF Post-Doc Fellow in tumor microenvironment and animal models lab, Institute of Life Sciences, Bhubaneswar, India, under the mentorship of Dr. Shantibhusan Senapati. She is primarily investigating the role of CAFs’ secretome in pancreatic cancer.

Abstract:

Macrophage migration inhibitory factor (MIF) is a cytokine having multiple functions in different types of cancers including pancreatic cancer (PC). Induced expression of MIF in PC tissue and its high expression in PDAC-derived exosomes provide strong rationale to investigate its association with PC. Cancer associated fibroblasts (CAFs), the major population of tumor microenvironment, are known to play crucial role in PC growth, progression and survival. The objectives of this study were to investigate the expression status of MIF and its receptors in CAFs and how their level of expression gets regulated in presence of inflammatory stimuli. To explore the secretome of human CAFs, a global proteomic profiling was carried out which showed that CAFs express MIF. To check the expression status of MIF and its receptors in CAFs in clinical scenario, CAFs were isolated from PC tissue of cancer patients through outgrowth method. Expression analysis of MIF and its receptors in CAFs (through qPCR, Western blot, immunofluorescence and FACS) and also in PC tissues in situ (through immunohistochemistry) show that CAFs express MIF. As inflammation is a contributing factor to MIF production and also has effect on PC, we further checked the expression of MIF and its receptors in CAFs following stimulation with LPS and TNF-a through qPCR, which showed that these inflammatory stimuli up-regulated the expression of both MIF and its receptors. Our ongoing work will shed light on the role of MIF in CAF’s pathophysiology, which may open up possibilities for targeted therapeutic strategies for PC.

Biography:

Mohammed  Noufal B has completed his MBBS and MD internal medicine from The Tamilnadu  Dr MGR Medical University. He is currently pursuing his post graduate course,DM  in medical gastroenterology at  the Madras Medical College Chennai,India.He has published  papers in reputed journals and conducting various research studies.

Abstract:

Introduction: Pneumatic dilation (PD) is considered to be the first line nonsurgical therapy for achalasia. The principle of the procedure is to weaken  the lower  esophageal sphincter by tearing its muscle fibers by generating radial force which is done endoscopically  without fluoroscopic control using  a low-compliance balloon such as  Rigiflex dilator . It has the advantage of determining mucosal injury during the dilation process, so that a repeat endoscopy is not needed to assess the mucosal tearing.

Aim: To study the series of cases of  achalasia  cardia, managed  by pneumatic dilatation and observe their efficacy, outcomes and complications presenting  in our centre during the period of July 2015 to 2017

Methods: 27 cases of achalasia cardia  which presented to our centre during July 2015 to 2017  and  managed by endoscope guided  pneumatic dilatation were retrospectively analysed and their outcomes were observed.

Results: 25 of 27 patients with achalasia presented with dysphagia for solids or liquids. 20 patients had regurgitation and vomiting. Weight loss of more than 5 Kg was observed in 10 patients. History of  nocturnal cough was present in 7 patients. 35 dilatations were performed in 27 patients. All patients had  relief of dysphagia and regurgitation within 24 hours. Barium swallow within a week of dilatation  showed a decrease in the maximum  diameter of the oesophagus from 42.4 + 11.4 mm to 30.5 + 10.5 mm and increase in the diameter of the narrowed lower segment  from 2.45 + 1.5 mm to 11.4+ 2.2 mm. None of the patients  showed a hold up of  barium after dilatation. 20 patients complained of retrosternal  pain during  procedure but none persisted for 24 hours. No perforations were encountered during the study. There was no procedural mortality .

Conclusions: Endoscope-guided PD is an efficient and safe nonsurgical therapy with results comparable to other treatment modalities.

Biography:

Dr. Thinakarmani has completed his MBBS at 23 years of age from pondicherry university and MD internal medicine from Manipal university (Gold medal with award for best outgoing students ), currently working us senior resident( Final year DM post graduate ) at institute of medical gastroenterology at Madras medical college, chennai, tamilnadu, india. He has presented many papers at national conferences all around India.

Abstract:

Background and Aims

The liver is integral to lipid metabolism and a compromise in its function leads to perturbations in these pathways. In this study we hope to determine the correlation between CLD severity and its effect on lipid parameters. We also look at the etiology specific effects on lipid levels.

Materials and Methods

This is a retrospective cross sectional analysis of 250 patients with cirrhosis compared to 250 healthy age and sex matched controls. Severity assessment of CLD using MELD and Child-Pugh scores was performed and etiological details collected. A questionnaire was used to obtain patient demographic details and lastly a fasting lipid profile (Total, LDL, HDL cholesterol, Triglycerides and VLDL) was obtained.

Results

All components of the lipid profile declined linearly with increasing severity of CLD as determined by MELD and Child-Pugh scores. Lipid levels were clearly lower in CLD patients as compared to healthy controls. Interestingly, preliminary analysis indicated that CLD of different etiologies had differential effects on Lipid profiles – This aspect is under further analysis.

Conclusions

All components of the lipid profile were definitely lower in CLD patients as compared to controls and demonstrated an inverse correlation with increasing severity. The utilization of this parameter as a prognosticating aid requires further study. Additionally preliminary analysis indicates that various CLD etiologies appear to have specific effects on the lipid profile – a finding under further analysis.

Biography:

Sibithooran K has completed his under-graduation from Sri Devaraj Urs Medical College, Kolar and his Masters in Internal Medicine from the Manipal University. He is currently a Resident of Gastroenterology at Madras Medical College, Chennai.

Abstract:

Background & Aims: To retrospectively analyze the effectiveness of the ERCP procedures done for post cholecystectomy bile duct injuries.

Materials & Methods: All the patients who underwent ERCP procedure for post cholecystectomy bile duct injuries during August 2015 to July 2017 were included in the study and the details were analyzed.

Results: A total of 49 patients underwent ERCP for management of bile duct injuries. 20 of them had type A Strasberg injury, 15 had Strasberg type D injury, 14 had Strasberg type C and Strasberg types B and E were managed surgically. Stenting was successful in 22/25 type A, 9/15 type D and 4/14 type C.

Conclusion: ERCP in post-surgical bile leaks was very effective with Strasberg type A injuries and to some extent in Strasberg type D was not so effective in type C.

Biography:

Sumita A Jain is a Senior Professor and Head of Surgical Unit in the Department of Surgery at Sawai Man Singh Medical College and Hospital, Jaipur, India. She is the Founder of Women Oncology and Healthcare Clinic in her hospital. She is also the President of an NGO, Women’s Cancer Society. She is the co-author of World Society of Emergency Surgery- Sepsis Severity Score. She has also co-authored many publications in leading journals and is Principal Investigator in multiple research trials in the field of women cancer.

Abstract:

Gastric volvulus is an uncommon condition. It occurs mainly as a result of congenital laxity of the stomach's attachments and might be accompanied by a diaphragmatic hernia. This sometimes causes the stomach to herniate into the thorax. It can be mesentricoaxial or organoaxial, former being rarer. We present our 2 patients who were managed with minimal invasive surgery. We managed two patients with gastric volvulus, both had mesentricoaxial gastric volvulus. One of the patient also had diaphragmatic hernia in which repair was done with mesh hernioplasty. Both patients recovered well from surgery. The average hospital stay was 3 days. Mesentricoaxial gastric volvulus is a rare disease and very few cases have been reported in the literature and there are combined endoscopic and laparoscopic approaches for treatment. In secondary volvulus, the diaphragmatic defect has to be repaired, preferably with mesh. Gastropexy is performed in all cases. Even though worldwide experience in laparoscopic surgery for gastric volvulus is limited, the results are encouraging. Based on our experience, laparoscopic management seems to be safe and feasible in the rare case of mesentricoaxial gastric volvulus.